I'm always going to get more of a charge playing Chicago than I will Duluth or some place like that. Just because of the history and the people there are way more knowledgeable than a lot of other cities. It's an amazing music scene with some great bands and great musicians.
If you have an impulse, not if you're going to ruin someone elses' scene, if you have an impulse of a funny little add-on or taking something in a weird direction, try it.